Plevitrexed is an orally bioavailable, small molecule, non-polyglutamatable, antifolate quinazoline analogue thymidine synthetase inhibitor with potential antineoplastic activity. Plevitrexed is transported into the cell via the physiological reduced folate carrier (RFC) system. Intracellularly, this agent selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, which may result in DNA synthesis inhibition and apoptosis. References: Lovelace LL, Gibson LM, Lebioda L. Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 2007 Mar 13;46(10):2823-30. Epub 2007 Feb 13. PubMed PMID: 17297914; PubMed Central PMCID: PMC2516748.

纯度：≥98%

CAS：153537-73-6