E6201 (E-6201) is a novel, potent, and fungal metabolite analog and inhibitor of MEK-1/MEKK-1 (mitogen-activated protein kinase kinase 1 and mitogen-activated protein kinase kinase kinase 1) with potential antipsoriatic, anti-inflammatory and antineoplastic activities. As a novel anti-inflammatory agent, it has potent inhibitory effects on the production of proinflammatory cytokines from leukocytes and antiproliferative activity on keratinocytes. E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers.

纯度：≥98%

CAS：603987-35-5