Perindoprilat (S-9490)) is a non-sulfhydryl and long-acting angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.05 nM. It is used for treating hypertension and heart failure. It can suppress the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice. Perindopril Erbumine displays a higher binding affinity for the bradykinin binding sites than the angiotensin I binding sites of ACE. Perindopril Erbumine inhibits the angiotensin- and Aβ42-to-Aβ40-converting activity of mutated ACE containing two active domains (F-ACE) with IC50 of 0.03-0.1 μM, and 0.01-0.03 μM, respectively.

纯度：≥98%

CAS：95153-31-4