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Delgocitinib(LEO124249 JTE052)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Delgocitinib(LEO124249 JTE052)图片
CAS NO:1263774-59-9
规格:≥98%
包装与价格：
包装价格(元)
1mg电议
2mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Delgocitinib (formerly LEO-124249; JTE052; LEO124249; JTE-052; Corectim) is a potent and selective JAK inhibitor with anti-inflammatory activities and has been approved in 2020 for use in Japan for the treatment of autoimmune disorders and hypersensitivity, including inflammatory skin conditions (e.g. atopic dermatitis). It inhibits JAK1, JAK2, JAK3 and Tyk2 with IC50s of 2.8, 2.6, 13 and 58 nM, respectively. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in Comparison with conventional therapeutic agents. JTE-052 regulates contact hypersensitivity by downmodulating T cell activation and differentiation.
理化性质和储存条件

Molecular Formula: C16H18N6O;

Exact Mass: 310.1542
Molecular Weight: 310.361
Elemental Analysis: C, 61.92; H, 5.85; N, 27.08; O, 5.15

Related CAS #: 1263774-59-9 (free) 2064338-33-4 (EtOH) 2064338-35-6 (CHCl3)

Synonym: LEO-124249; JTE-052; LEO 124249; JTE 052; LEO124249; JTE052;

Chemical Name:3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile

InChi Key:LOWWYYZBZNSPDT-ZBEGNZNMSA-N

InChi Code:InChI=1S/C16H18N6O/c1-11-8-22(13(23)2-5-17)16(11)4-7-21(9-16)15-12-3-6-18-14(12)19-10-20-15/h3,6,10-11H,2,4,7-9H2,1H3,(H,18,19,20)/t11-,16-/m0/s1

SMILES Code:N#CCC(N1C[C@H](C)[C@]12CN(C3=C4C(NC=C4)=NC=N3)CC2)=O