Delequamine, also known RS-15385 or RS-15385-197 (HCl salt), is a potent and selective alpha 2-adrenoceptor antagonist. RS-15385-197 had a pKi of 9.45 for alpha 2-adrenoceptors in the rat cortex (pA2 in the guinea-pig ileum of 9.72). RS-15385-197 was highly selective for alpha 2-adrenoceptors over the compound showed low affinity for 5-HT1A (pKi 6.50) and 5-HT1D (pKi 7.00) receptor subtypes, and even lower affinity (pKi < or = 5) for other 5-HT receptor subtypes, dopamine receptors, muscarinic cholinoceptors, beta-adrenoceptors and dihydropyridine binding sites. References: Padma-Nathan H, Christ G, Adaikan G, Becher E, Brock G, Carrier S, Carson C, Corbin J, Francis S, DeBusk R, Eardley I, Hedlund H, Hutter A, Jackson G, Kloner R, Lin CS, McVary K, McCullough A, Nehra A, Porst H, Schulman C, Seftel A, Sharlip I, Stief C, Teloken C. Pharmacotherapy for erectile dysfunction. J Sex Med. 2004 Sep;1(2):128-40. Erratum in: J Sex Med. 2005 Jan;2(1):158. Lin, Shin [corrected to Lin, Ching-Shwun]. PubMed PMID: 16422967.

纯度：≥98%

CAS：119942-75-5