DG-172 is an orally bioavailable potent PPARβ/δ inverse agonist (IC50 = 26.9 nM). DG-172 inhibits Angptl4 gene expression in mouse myoblasts (IC50 = 9.5 nM) in vitro. DG172 triggers a PPARβ/δ-independent myeloid lineage shift and promotes GM-CSF/IL-4-induced dendritic cell differentiation. References: Yao PL, Chen L, Hess RA, Müller R, Gonzalez FJ, Peters JM. Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling. J Biol Chem. 2015 Sep 18;290(38):23416-31. doi: 10.1074/jbc.M115.664508. Epub 2015 Aug 4. PubMed PMID: 26242735; PubMed Central PMCID: PMC4645614.

纯度：≥98%

CAS：1361504-77-9