PKI 14-22 amide, myristoylated, formerly known as myristoylated protein kinase A inhibitor amide 14-22, is a PKA inhibitor. PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1). References: Nalli AD, Kumar DP, Mahavadi S, Al-Shboul O, Alkahtani R, Kuemmerle JF, Grider JR, Murthy KS. Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-κB/AMP-activated kinase/myosin light chain kinase pathway. J Pharmacol Exp Ther. 2014 Jul;350(1):89-98. doi: 10.1124/jpet.113.212522. Epub 2014 Apr 25. PubMed PMID: 24769544; PubMed Central PMCID: PMC4056271.

纯度：≥98%

CAS：201422-03-9