Diprovocim is a novel and potent agonist of Toll-like receptor (TLR1/TLR2) with anticancer and immunomodulatory effects. It induces dose-dependent TNF production with an EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages. Inducing TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also inducing IL-6 production by mouse BMDC; inducing phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activating conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling; synergizes with anti-PD-L1 to eliminate melanoma in mice.

纯度：≥98%

CAS：2170867-89-5