DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally , and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally . References: Wang J, Mook RA Jr, Ren XR, Zhang Q, Jing G, Lu M, Spasojevic I, Lyerly HK, Hsu D, Chen W. Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. Bioorg Med Chem. 2018 Sep 17. pii: S0968-0896(18)31138-6. doi: 10.1016/j.bmc.2018.09.016. [Epub ahead of print] PubMed PMID: 30274939.

纯度：≥98%

CAS：2102672-22-8