TXA127, formerly known as Angiotensin i (1-7), is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phophorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 Mapk signaling pathway. References: Abrigo J, Simon F, Cabrera D, Cabello-Verrugio C. Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation. Cell Physiol Biochem. 2016 Nov 14;40(1-2):27-38. [Epub ahead of print] PubMed PMID: 27842312.

纯度：≥98%

CAS：51833-78-4