DNS-8254 is a potent and selective Phosphodiesterase 2 (PDE2) Inhibitor for the Treatment of Memory Disorders (hPDE2a IC50 = 8 nM, Rat Cl-int = 25.6 uL/min/mg). In vivo, DNS-8254 demonstrated significant memory enhancing effects in a rat model of novel object recognition. DNS-8254 may be a useful tool to explore the pharmacology of selective PDE2a inhibition. References: Gomez L, Massari ME, Vickers T, Freestone G, Vernier WF, Ly K, Xu R, McCarrick M, Marrone T, Metz M, Yan YG, Yoder ZW, Lemus R, Broadbent NJ, Barido R, Warren N, Schmelzer K, Neul D, Lee D, Andersen CB, Sebring K, Aertgeerts K, Zhou X, Tabatabaei A, Peters M, Breitenbucher JG. Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2) Inhibitors for the Treatment of Memory Disorders. J Med Chem. 2017 Feb 6. doi: 10.1021/acs.jmedchem.6b01793. [Epub ahead of print] PubMed PMID: 28165743.

纯度：≥98%

CAS：1821107-98-5