Licostinel, formerly known as ACEA-1021 and CGP-63446, is a glutamate receptor antagonist potentially for the treatment of pain and stroke. Intravenous Licostinel reduced cerebral infarction by 62% (15 min treatment delay) and 42% (2 h treatment delay), relative to vehicle-injected rats, when subjected to a modified Tamura and permanent intraluminal filament model of stroke, respectively. Licostinel protects against permanent focal cerebral ischemia. References: Qiu W, Wei R, Zhang C, Zhang C, Leng W, Wang W. A glycine site-specific NMDA receptor antagonist protects retina ganglion cells from ischemic injury by modulating apoptotic cascades. J Cell Physiol. 2010 Jun;223(3):819-26. doi: 10.1002/jcp.22118. PubMed PMID: 20333677.

纯度：≥98%

CAS：153504-81-5