XR-5000, formerly known as DACA and SN 22995, is a DNA topoisomerase I and II inhibitor potentially for the treatment of colorectal cancer, glioblastoma. Topoisomerases I and II unravel DNA during transcription, DNA replication and DNA repair. Inhibitors of both enzymes are important anticancer drugs, but only now are combined inhibitors becoming available for clinical use. References: Soo JC, Lee EG, Lee LA, Kashon ML, Harper M. Evaluation of pump pulsation in respirable size-selective sampling: Part III. Investigation of European standard methods. Ann Occup Hyg. 2014 Oct;58(8):1006-17. doi: 10.1093/annhyg/meu047. PubMed PMID: 25053700; PubMed Central PMCID: PMC4702258.

纯度：≥98%

CAS：89459-25-6