CAS NO: | 1356918-39-2 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
DS-8587 is a DNA topoisomerase inhibitor potentially for the treatment of bacterial infection. DS-8587 significantly reduced the number of viable bacteria in a murine model of F. necrophorum-induced liver abscess. DS-8587 exhibits potent antibacterial activity against quinolone-resistant A. baumannii isolates that harbor mutations in quinolone resistance-determining regions. In the presence of the efflux pump inhibitor 1-(1-napthylmethyl)-piperazine, no significant changes were observed in the MIC for DS-8587. References: Nagaoka K, Yanagihara K, Morinaga Y, Kurosaka Y, Hoshino K, Kohno S. In vivo antianaerobe activity of DS-8587, a new fluoroquinolone, against Fusobacterium necrophorum in a mouse model. J Infect Chemother. 2017 Mar;23(3):131-135. doi: 10.1016/j.jiac.2016.09.007. PubMed PMID: 28109739.
纯度:≥98%
CAS:1356918-39-2