Cilastatin sodium (formerly known as MK-791; MK0791; Recarbrio), the sodium salt of Cilastatin, is a renal dehydropeptidase inhibitor, as well as a leukotriene D4 dipeptidase inhibitor with nephroprotective effects. Dehydropeptidase is an enzyme found in the kidney and is responsible for degrading the antibiotic imipenem. Cilastatin can therefore be combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta-lactamase that usually confer antibiotic resistance to certain bacteria.

纯度：≥98%

CAS：81129-83-1