Gly-Pro-Glu, formerly known as GPE, is a neuroprotective agent and the N-terminal tripeptide of IGF-1. Gly-Pro-Glu is neuroprotective after central administration in animal models of neurodegenerative processes, such as Huntington’s, Parkinson’s, Alzheimer’s diseases, and varies acute brain injury animal models. GPE mimics insulin-like growth factor I effects on the somatostatin system through a mechanism independent of β-amyloid clearance that involves modulation of calcium and glycogen synthase kinase 3β signaling. References: Vaaga CE, Tovar KR, Westbrook GL. The IGF-derived tripeptide Gly-Pro-Glu is a weak NMDA receptor agonist. J Neurophysiol. 2014 Sep 15;112(6):1241-5. doi: 10.1152/jn.00290.2014. Epub 2014 Jun 18. PubMed PMID: 24944213; PubMed Central PMCID: PMC4137256.

纯度：≥98%

CAS：32302-76-4