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TP-300
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:534605-78-2
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

TP-300, formerly known as CH-0793076; TP-3076, is a DNA topoisomerase I inhibitor potentially for the treatment of colorectal cancer, gastric cancer. TP300 is stable in an acidic solution but is rapidly converted to CH0793076 under physiological pH conditions such as in sera. This efficient prodrug activation would minimize interpatient differences in pharmacokinetic and toxicity profiles. Unlike CPT-11, TP300 does not exhibit cholinergic interaction or cause acute diarrhea at effective doses. In mouse xenograft models, TP300 showed antitumor activity against both BCRP-positive and -negative xenografts, whereas CPT-11 was less active against BCRP-positive xenografts. References:

纯度:≥98%

CAS:534605-78-2