FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models. References: You CG, Sheng HS, Xie CR, Zhang N, Zheng XS. FM19G11 inhibits O(6) -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 May 15. doi: 10.1002/cam4.1551. [Epub ahead of print] PubMed PMID: 29761922; PubMed Central PMCID: PMC6051152.

纯度：≥98%

CAS：329932-55-0