Tomelukast, formerly known as LY171883, is a leukotriene inhibitor. Tomelukast showed protective effects in traumatic shock. LY-171883 stimulates the activity of BK(Ca) channels in a manner unlikely to be linked to its blockade of leukotriene receptors or stimulation of peroxisome proliferator-activated receptors. The stimulatory effects on these channels may, at least in part, contribute to the underlying cellular mechanisms by which LY-171883 affects neuronal or neuroendocrine function. References: Moreno JJ. Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis. Eur J Pharmacol. 2016 Dec 7;796:7-19. doi: 10.1016/j.ejphar.2016.12.004. [Epub ahead of print] Review. PubMed PMID: 27940058.

纯度：≥98%

CAS：88107-10-2