MGS-0039, formerly known as BCI-632, is a group II metabotropic glutamate receptor (mgluR2/3) antagonist potentially for the treatment of cognitive disorders, depression and anxiety. Antidepressant-like action of group II mGlu receptor antagonists does not depend on serotonergic system activation. However, the AMPA receptor seems to play a key role in the antidepressant-like action of these compounds. Dopamine release in the NAc shell is regulated by mGlu 2/3 receptors. References: Palucha-Poniewiera A, Wierońska JM, Brański P, Stachowicz K, Chaki S, Pilc A. On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039. Psychopharmacology (Berl). 2010 Dec;212(4):523-35. doi: 10.1007/s00213-010-1978-5. PubMed PMID: 20703449; PubMed Central PMCID: PMC2981731.

纯度：≥98%

CAS：569686-87-9