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R(+)-SKF-38393A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
R(+)-SKF-38393A图片
CAS NO:81702-42-3
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)291.77
FormulaC16H17NO2 . HCl
CAS No.81702-42-3 (R-isomer HCl);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 58 mg/mL (198.8 mM)
Water: <1 mg/mL
Ethanol: 6 mg/mL (20.6 mM)
SMILES Code OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl
Synonyms SKF-38393; SKF 38393; SKF38393; SKF-38,393; SKF 38,393; SKF38,393; SKF-38393 HCl; SKF-38393 hydrochloride; SKF-38393A; SKF 38393A; SKF38393A; R(+)-SKF-38393A; R(+) SKF 38393A; R(+)SKF38393A; R-SKF-38393A; R SKF 38393A; RSKF38393A;
实验参考方法
In Vitro

In vitro activity: SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations.


Kinase Assay: SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.


Cell Assay:

In VivoSKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning.
Animal modelMale Wistar rats
Formulation & DosageDissolved in saline; 6 mg/kg; i.p. injection
References Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2446-50; Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7.