Olorofim (previously F-901318; F901318) is a novel, oral and potent DHODH (dihydroorotate dehydrogenase) inhibitor with a potential for the treatment of invasive aspergillosis. It is the first member of the orotomide class of antifungals. F-901318 exhibit s excellent potency against a broad range of dimorphic and filamentous fungi and is being evaluated in clinical trials for the treatment of invasive mold infections. Olorofim inhibits dihydroorotate dehydrogenase, which is a key enzyme in the biosynthesis of pyrimidines. Olorofim has activity against many molds and thermally dimorphic fungi, including species that are resistant to azoles and amphotericin B, but lacks activity against yeasts and the Mucorales. It is currently being developed for both oral and intravenous administration. Although published clinical outcome data have been limited to case reports to date, the results against invasive and refractory infections are promising.

纯度：≥98%

CAS：1928707-56-5