MK-212 is a 5HT2C-receptor agonist. A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice. References: Kozhevnikova LM, Mesitov MV, Moskovtsev AA. [Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II]. Patol Fiziol Eksp Ter. 2014 Oct-Dec;(4):17-29. Russian. PubMed PMID: 25980223. 2: Kuznetsova EG, Amstislavskaya TG, Bulygina VV, Tibeikina MA, Popova NK. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med. 2006 Nov;142(5):594-7. PubMed PMID: 17415471. 3: de Mello Cruz AP, Pinheiro G, Alves SH, Ferreira G, Mendes M, Faria L, Macedo CE, Motta V, Landeira-Fernandez J. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl). 2005 Nov;182(3):345-54. Epub 2005 Oct 19. PubMed PMID: 16133141. 4: Halford JC, Lawton CL, Blundell JE. The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence. Pharmacol Biochem Behav. 1997 Jan;56(1):41-6. PubMed PMID: 8981607. 5: Hemrick-Luecke SK, Fuller RW. Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212. Eur J Pharmacol. 1996 Sep 12;311(2-3):207-11. PubMed PMID: 8891601. 6: Meltzer HY, Maes M. Effect of pindolol pretreatment on MK-212-induced plasma cortisol and prolactin responses in normal men. Biol Psychiatry. 1995 Sep 1;38(5):310-8. PubMed PMID: 7495925. 7: Friedman L, Jesberger JA, Meltzer HY. The effect of apomorphine, MK-212 (6-chloro-2-[1-piperazinyl]-pyrazine) and placebo on smooth pursuit gain and corrective saccades in normal subjects. Neuropsychopharmacology. 1994 Aug;11(1):49-62. PubMed PMID: 7945744. 8: Lee MA, Meltzer HY. Blunted oral body temperature response to MK-212 in cocaine addicts. Drug Alcohol Depend. 1994 Jun;35(3):217-22. PubMed PMID: 7956751. 9: Li Q, Brownfield MS, Battaglia G, Cabrera TM, Levy AD, Rittenhouse PA, van de Kar LD. Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonists 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI). J Pharmacol Exp Ther. 1993 Aug;266(2):836-44. PubMed PMID: 8394920. 10: Cooper SJ, Barber DJ. Effects of d-fenfluramine, MK-212, and ondansetron on saline drinking in two-choice tests in the rehydrating rat. Pharmacol Biochem Behav. 1993 Jul;45(3):593-6. PubMed PMID: 8332621. 1 Van de Kar LD, Rittenhouse PA, O'Connor P, Palionis T, Brownfield MS, Lent SJ, Carnes M, Bethea CL. Effect of cocaine injections on the neuroendocrine response to the serotonin agonist MK-212. Biol Psychiatry. 1992 Aug 1;32(3):258-69. PubMed PMID: 1330009. 12: Lee HS, Bastani B, Friedman L, Ramirez L, Meltzer HY. Effect of the serotonin agonist, MK-212, on body temperature in schizophrenia. Biol Psychiatry. 1992 Mar 1;31(5):460-70. PubMed PMID: 1581424. 13: Bastani B, Nash JF, Meltzer HY. Prolactin and cortisol responses to MK-212, a serotonin agonist, in obsessive-compulsive disorder. Arch Gen Psychiatry. 1990 Sep;47(9):833-9. PubMed PMID: 2203327. 14: McKearney JW. Effects of serotonin agonists on operant behavior in the squirrel monkey: quipazine, MK-212, trifluoromethylphenylpiperazine, and chlorophenylpiperazine. Pharmacol Biochem Behav. 1990 Jan;35(1):181-5. PubMed PMID: 2315357. 15: Reis LC, Ramalho MJ, Antunes-Rodrigues J. Central serotonergic modulation of drinking behavior induced by angiotensin II and carbachol in normally hydrated rats: effect of intracerebroventricular injection of MK-212. Braz J Med Biol Res. 1990;23(12):1339-42. PubMed PMID: 2136567. 16: Reis LC, Ramalho MJ, Antunes-Rodrigues J. Central serotonergic modulation of drinking behavior induced by water deprivation: effect of a serotonergic agonist (MK-212) administered intracerebroventricularly. Braz J Med Biol Res. 1990;23(12):1335-8. PubMed PMID: 2136566. 17: King BH, Brazell C, Dourish CT, Middlemiss DN. MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype. Neurosci Lett. 1989 Oct 23;105(1-2):174-6. PubMed PMID: 2562060. 18: McKearney JW. Apparent antinociceptive properties of piperazine-type serotonin agonists: trifluoromethylphenylpiperazine, chlorophenylpiperazine, and MK-212. Pharmacol Biochem Behav. 1989 Mar;32(3):657-60. PubMed PMID: 2740421. 19: Lowy MT, Meltzer HY. Stimulation of serum cortisol and prolactin secretion in humans by MK-212, a centrally active serotonin agonist. Biol Psychiatry. 1988 Apr 15;23(8):818-28. PubMed PMID: 3365458. 20: Cunningham KA, Callahan PM, Appel JB. Discriminative stimulus properties of the serotonin agonist MK 212. Psychopharmacology (Berl). 1986;90(2):193-7. PubMed PMID: 3097699.

纯度：≥98%

CAS：64022-27-1