Monepantel, formerly known as AAD 1566, is a new anthelmintic agent approved for the treatment of nematode infections in farm animals. As a nematicide, it acts through a nematode-specific nicotinic receptor subtype which explains its exceptional safety in rodents and mammals. Monepantel is also a promising anticancer agent, which suppressed cellular thymidine incorporation thus impairing DNA synthesis and inducing cleavage of poly (ADP-ribose) polymerase (PARP-1). References: Cintra MC, Teixeira VN, Nascimento LV, Sotomaior CS. Lack of efficacy of monepantel against Trichostrongylus colubriformis in sheep in Brazil. Vet Parasitol. 2016 Jan 30;216:4-6. doi: 10.1016/j.vetpar.2015.11.013. Epub 2015 Nov 28. PubMed PMID: 26801587.

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CAS：887148-69-8