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FN-1501
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1429515-59-2
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

FN-1501 is a potent a FLT3/CDKs kinase inhibitor with potential high efficiency against acute myelocytic leukemia (AML). FN-1501, which possesses potent inhibitory activities against FLT3, CDK2, CDK4, and CDK6 with IC50 in the nanomolar range, shows antiproliferative activities against MV4-11 cells ( 0.008 μM), which correlates with the suppression of retinoblastoma phosphorylation, FLT3, ERK, AKT, and STAT5 and the onset of apoptosis. Acute-toxicity studies in mice show that FN-1501 ( 186 mg/kg) is safer than AT7519 (32 mg/kg). In MV4-11 xenografts in a nude-mouse model, FN-1501 can induce tumor regression at the dose of 15 mg/kg, which is more efficient than cytarabine (50 mg/kg). References: Wang Y, Zhi Y, Jin Q, Lu S, Lin G, Yuan H, Yang T, Wang Z, Yao C, Ling J, Guo H, Li T, Jin J, Li B, Zhang L, Chen Y, Lu T. Discovery of 4-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), as a FLT3/CDKs kinase inhibitor with potential high efficiency against acute myelocytic leukemia (AML). J Med Chem. 2018 Jan 22. doi: 10.1021/acs.jmedchem.7b01261. [Epub ahead of print] PubMed PMID: 29357250.

纯度:≥98%

CAS:1429515-59-2