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Fmoc-Val-Cit-PAB-PNP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fmoc-Val-Cit-PAB-PNP图片
CAS NO:863971-53-3
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍

Fmoc-Val-Cit-PAB-PNP is a linker for Antibody-Drug-Conjugation (ADC). The Val-Cit will specifically be cleaved by catepsin B. Because this enzyme is only present in the lysosome, the ADC payload will only be released in the cell. The azido group will react with DBCO, BCN or other alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. References: Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc400050k. Epub 2013 May 3. PubMed PMID: 23600922; PubMed Central PMCID: PMC3674550.

纯度:≥98%

CAS:863971-53-3