FR 139317 is a highly potent and selective ETA endothelin receptor antagonist (Kis are 1 nM and 7.3 μM at ETA and ETB subtypes respectively). It is active in vivo. References: Michinaga S, Nagase M, Matsuyama E, Yamanaka D, Seno N, Fuka M, Yamamoto Y, Koyama Y. Amelioration of cold injury-induced cortical brain edema formation by selective endothelin ETB receptor antagonists in mice. PLoS One. 2014 Jul 7;9(7):e102009. doi: 10.1371/journal.pone.0102009. eCollection 2014. PubMed PMID: 25000290; PubMed Central PMCID: PMC4084986.

纯度：≥98%

CAS：142375-60-8