Tebuquine, also known CI-897 and WR-228258, is an antimalarial agent. WR-225,448 is active against P. falciparum in vitro. WR 228,258 in vitro shows a chloroquine-like effect, but not in vivo, suggesting that its mode of action in vivo is different from that of chloroquine. WR 225,448 has no action in the CIPC in vitro and affects primarily mitochondria of the parasites in vivo. It probably acts through a metabolite. Both pre-erythrocytic and erythrocytic stages of rodent malaria parasites are affected by WR 225,448. References: Romero AH, Acosta ME, Gamboa N, Charris JE, Salazar J, López SE. Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy isotebuquine derivatives against Plasmodium berghei. Bioorg Med Chem. 2015 Aug 1;23(15):4755-62. doi: 10.1016/j.bmc.2015.05.040. PubMed PMID: 26081761.

纯度：≥98%

CAS：74129-03-6