G-5555 is a potent and selective PAK1 inhibitor. G-5555 showed excellent kinase selectivity and inhibited only eight out of the 235 kinases tested other than PAK1 with inhibition >70%: PAK2, PAK3, KHS1, Lck, MST3, MST4, SIK2, and YSK1. G-5555 demonstrated in vivo PK/PD effects consistent with the observed potency and pharmacokinetic properties. G-5555 may be a potential cancer drug candidate. The p21-activated kinases (PAKs), which belong to the sterile-20 (STE20) family of kinases, play important roles in the regulation of key cellular phenomena including cell migration, proliferation, and survival mechanisms. References:

纯度：≥98%

CAS：1648863-90-4