MK-9470 is a selective, high affinity inverse agonist that has been used to image the cannabinoid receptor type 1 in human brain in healthy and disease states. It also a fluorine-18-labeled positron emission tomography (PET) radiotracer [(18) F]. References: Ceccarini J, Kuepper R, Kemels D, van Os J, Henquet C, Van Laere K. [18F]MK-9470 PET measurement of cannabinoid CB1 receptor availability in chronic cannabis users. Addict Biol. 2015 Mar;20(2):357-67. doi: 10.1111/adb.12116. Epub 2013 Dec 27. PubMed PMID: 24373053. 2: Ly HG, Ceccarini J, Weltens N, Bormans G, Van Laere K, Tack J, Van Oudenhove L. Increased cerebral cannabinoid-1 receptor availability is a stable feature of functional dyspepsia: a [F]MK-9470 PET study. Psychother Psychosom. 2015;84(3):149-58. doi: 10.1159/000375454. Epub 2015 Mar 28. PubMed PMID: 25833408. 3: Verdurand M, Dalton VS, Nguyen V, Grégoire MC, Zahra D, Wyatt N, Burgess L, Greguric I, Zavitsanou K. 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PubMed PMID: 23836381. 6: Emonds KM, Koole M, Casteels C, Van den Bergh L, Bormans GM, Claus F, De Wever L, Lerut E, Van Poppel H, Joniau S, Dumez H, Haustermans K, Mortelmans L, Goffin K, Van Laere K, Deroose CM, Mottaghy FM. 18F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study. EJNMMI Res. 2013 Aug 2;3(1):59. doi: 10.1186/2191-219X-3-59. PubMed PMID: 23915639; PubMed Central PMCID: PMC3750838. 7: Casteels C, Koole M, Celen S, Bormans G, Van Laere K. Preclinical evaluation and quantification of [18F]MK-9470 as a radioligand for PET imaging of the type 1 cannabinoid receptor in rat brain. Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1467-77. doi: 10.1007/s00259-012-2163-3. Epub 2012 Jun 15. PubMed PMID: 22699528. 8: Verdurand M, Nguyen V, Stark D, Zahra D, Gregoire MC, Greguric I, Zavitsanou K. Comparison of Cannabinoid CB(1) Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [F]MK-9470. 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The effect of anaesthesia on [(18)F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain. Eur J Nucl Med Mol Imaging. 2010 Jun;37(6):1164-73. doi: 10.1007/s00259-010-1383-7. Epub 2010 Feb 25. PubMed PMID: 20182714. 12: Sanabria-Bohórquez SM, Hamill TG, Goffin K, De Lepeleire I, Bormans G, Burns HD, Van Laere K. Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain. Eur J Nucl Med Mol Imaging. 2010 May;37(5):920-33. doi: 10.1007/s00259-009-1340-5. Epub 2009 Dec 24. PubMed PMID: 20033684. 13: Van Laere K, Koole M, Sanabria Bohorquez SM, Goffin K, Guenther I, Belanger MJ, Cote J, Rothenberg P, De Lepeleire I, Grachev ID, Hargreaves RJ, Bormans G, Burns HD. Whole-body biodistribution and radiation dosimetry of the human cannabinoid type-1 receptor ligand 18F-MK-9470 in healthy subjects. J Nucl Med. 2008 Mar;49(3):439-45. doi: 10.2967/jnumed.107.047290. Epub 2008 Feb 20. 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PubMed PMID: 18077184. 16: Burns HD, Van Laere K, Sanabria-Bohórquez S, Hamill TG, Bormans G, Eng WS, Gibson R, Ryan C, Connolly B, Patel S, Krause S, Vanko A, Van Hecken A, Dupont P, De Lepeleire I, Rothenberg P, Stoch SA, Cote J, Hagmann WK, Jewell JP, Lin LS, Liu P, Goulet MT, Gottesdiener K, Wagner JA, de Hoon J, Mortelmans L, Fong TM, Hargreaves RJ. [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9800-5. Epub 2007 May 29. PubMed PMID: 17535893; PubMed Central PMCID: PMC1877985.

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