GGTI-2133 is a peptidomimetic inhibitor of geranylgeranyl transferase type I (GGTase I; IC50 = 38 nM). GGTI-2133 inhibits infiltration of inflammatory cells into airways in mouse experimental asthma. GGTI-2133 increase erythrocyte deformability but reduce low O(2) tension-induced ATP release. References: Abdullah MI, Abed MN, Richardson A. Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Sci Rep. 2017 Aug 14;7(1):8090. doi: 10.1038/s41598-017-08649-9. PubMed PMID: 28808351; PubMed Central PMCID: PMC5556066.

纯度：≥98%

CAS：191102-79-1