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Daidzein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Daidzein图片
CAS NO:486-66-8
规格:≥98%
包装与价格:
包装价格(元)
500mg电议
1g电议
2g电议
5g电议
10g电议
100g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)254.24
FormulaC15H10O4
CAS No.486-66-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 51 mg/mL (200.6 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)

Chemical Name: 4',7-Dihydroxyisoflavone

InChi Key: ZQSIJRDFPHDXIC-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H

SMILES Code: O=C1C(C2=CC=C(O)C=C2)=COC3=C1C=CC(O)=C3

Synonyms

Daidzein; Daidzeol; Isoaurostatin

实验参考方法
In Vitro

In vitro activity: Daidzein inhibits iNOS protein and mRNA expression and also NO production in a dose-dependent manner. Daidzein also inhibits the activation of the signal transducer and activator of transcription 1 (STAT-1), another important transcription factor for iNOS. Daidzein (1 μM and 10 μM) causes a significant elevation of protein content, alkaline phosphatase activity, and DNA content in cells; those increases are about 1.4-, 1.5-, and 2.0-fold, respectively. Daidzein (2-50 mM) increases the viability of osteoblasts by about 1.4-fold. Daidzein (2-100 mM) increases the alkaline phosphatase activity and osteocalcin synthesis of osteoblasts by about 1.4- and 2.0-fold, respectively. Daidzein stimulates osteoblast differentiation at various stages (from osteoprogenitors to terminally differentiated osteoblasts). Daidzein (1 μM and 10 μM) causes a significant increase of alkaline phosphatase activity, deoxyribonucleic acid (DNA) and calcium contents in bone tissues. Daidzein-induced increase of calcium content and alkaline phosphatase activity in bone tissues is completely prevented by cycloheximide (1 μM).

In VivoDaidzein results in reduced body weight, a fact that may be explained by reduced feed consumption in female rats. Daidzein results in slight, but not significant, decreases in ovarian and uterine weights, and mammary gland size in female rats.
Animal modelRats
Formulation & Dosage
References

Mediators Inflamm. 2007;2007:45673; Biochem Pharmacol. 2000 Mar 1;59(5):471-5; Toxicol Sci. 2002 Feb;65(2):228-38.