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GSK1702934A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:924377-85-5
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

GSK1702934A is a a TRPC3 activator. SK1702934A induced a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but lacked significant electrophysiological effects in wild-type myocytes. GSK1702934A transiently enhanced contractility and evoked arrhythmias in isolated Langendorff hearts from TRPC3-overexpressing but not wild-type mice. References: Doleschal B, Primessnig U, Wolkart G, Wolf S, Schernthaner M, Lichtenegger M, Glasnov TN, Kappe CO, Mayer B, Antoons G, Heinzel F, Poteser M, Groschner K. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc Res. 2015 Apr 1;106(1):163-73. doi: 10.1093/cvr/cvv022. Epub 2015 Jan 28. PubMed PMID: 25631581; PubMed Central PMCID: PMC4362401.

纯度:≥98%

CAS:924377-85-5