Gue1654 is a oxoeicosanoid receptor 1 (OXE-R) modulator. Gue1654 selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue1654 inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells. References: Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochem Pharmacol. 2015 Aug 1;96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. PubMed PMID: 26032638; PubMed Central PMCID: PMC4830392.

纯度：≥98%

CAS：397290-30-1