GYKI53655 Hydrochloride is a non-competitive AMPA and kainate receptor antagonist. GYKI53655 Hydrochloride exhibits anticonvulsant activity. GYKI53655 Hydrochloride also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations. References: Miyazaki S, Minami T, Mizuma H, Kanazawa M, Doi H, Matsumura S, Lu J, Onoe H, Furuta K, Suzuki M, Ito S. The action site of the synthetic kainoid (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, for allodynia (tactile pain). Eur J Pharmacol. 2013 Jun 15;710(1-3):120-7. doi: 10.1016/j.ejphar.2012.10.023. PubMed PMID: 23124023.

纯度：≥98%

CAS：143692-48-2