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LGK-974
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LGK-974图片
CAS NO:1243244-14-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
LGK974, LGK 974
产品介绍

生物活性

LGK974是高效,选择性和口服生物利用性的豪猪抑制剂(Wnt信号拮抗剂),在Wnt信号报告基因测定和豪猪结合测定中IC50 <1 nM。

靶点信息

Porcn (TM3 cells)

化学数据

目录号A12816
作用机制Inhibitor (抑制剂)
M. Wt396.44
FormulaC23H20N6O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1243244-14-5
SynonymsLGK974, LGK 974
SMILESCC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C

溶解度

In vitro (25°C)DMSOWarmed: 76 mg/mL (191.7 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+corn oil4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.22 mL126.12 mL252.24 mL
0.5 mM5.04 mL25.22 mL50.45 mL
1 mM2.52 mL12.61 mL25.22 mL
5 mM0.5 mL2.52 mL5.04 mL

*The above data is based on the productmolecular weight 396.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.