L-748337 is a competitive β3-adrenoceptor antagonist that exhibits selectivity over β1 and β2 receptors (Kis are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). L-748337 inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM). References: Wang X, Wang R, Liu G, Dong J, Zhao G, Tian J, Sun J, Jia X, Wei L, Wang Y, Li W. The β3 Adrenergic Receptor Agonist BRL37344 Exacerbates Atrial Structural Remodeling Through iNOS Uncoupling in Canine Models of Atrial Fibrillation. Cell Physiol Biochem. 2016;38(2):514-30. doi: 10.1159/000438647. PubMed PMID: 26828873.

纯度：≥98%

CAS：244192-94-7