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Netupitant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Netupitant图片
CAS NO:290297-26-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
D05152, AG-E-94200
产品介绍

生物活性

Netupitant是一种选择性的神经激肽1(NK1)受体拮抗剂。它竞争性地结合并阻断中枢神经系统(CNS)中人类物质P/NK1受体的活性,从而抑制内源性速激肽神经肽物质P(SP)的NK1受体结合,这可能导致预防化疗引起的恶心和呕吐(CINV)。

靶点信息

neurokinin 1 receptor

化学数据

目录号A14428
作用机制Antagonist (拮抗剂)
M. Wt578.59
FormulaC30H32F6N4O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.290297-26-6
SynonymsD05152, AG-E-94200
SMILESCC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C

溶解度

In vitroDMSO2 mg/mL (3.45 mM)
WaterInsoluble
Ethanol85 mg/mL (146.91 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.28 mL86.42 mL172.83 mL
0.5 mM3.46 mL17.28 mL34.57 mL
1 mM1.73 mL8.64 mL17.28 mL
5 mM0.35 mL1.73 mL3.46 mL

*The above data is based on the productmolecular weight 578.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.