NBI-30775, formerly known as R121919, is a CRF1 receptor antagonist. R121919 attenuates the severity of precipitated morphine. Treatment with R121919 improves sleep-EEG in patients with depression. R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety. References: Hanson ND, Nemeroff CB, Owens MJ. Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus. J Pharmacol Exp Ther. 2011 Apr;337(1):180-6. doi: 10.1124/jpet.110.175372. Epub 2011 Jan 10. PubMed PMID: 21220416; PubMed Central PMCID: PMC3063735.

纯度：≥98%

CAS：195055-03-9