生物活性
BX471是一种有效的选择性非肽CCR1拮抗剂（对于人CCR1，Ki = 1 nM），对CCR1的选择性是CCR2，CCR5和CXCR4的250倍。
化学数据
| 目录号 | A14409 |
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 434.89 |
| Formula | C21H24ClFN4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 217645-70-0 |
| Synonyms | BX-471, BX 471 |
| SMILES | CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.99 mL | 114.97 mL | 229.94 mL |
| 0.5 mM | 4.6 mL | 22.99 mL | 45.99 mL |
| 1 mM | 2.3 mL | 11.5 mL | 22.99 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.6 mL |
*The above data is based on the productmolecular weight 434.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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