P-2281 is a mTOR inhibitor and is efficacious in a murine model of human colitis. In the dextran sulfate sodium (DSS) model of colitis, macroscopic colon observations demonstrated that P2281 significantly inhibited DSS-induced weight loss, improved rectal bleeding index, decreased disease activity index, and reversed DSS-induced shortening of the colon. References: AbuRahma AF, Abu-Halimah S, Hass SM, Nanjundappa A, Stone PA, Mousa A, Lough E, Dean LS. Carotid artery stenting outcomes are equivalent to carotid endarterectomy outcomes for patients with post-carotid endarterectomy stenosis. J Vasc Surg. 2010 Nov;52(5):1180-7. doi: 10.1016/j.jvs.2010.06.074. Epub 2010 Aug 8. PubMed PMID: 20692794.

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CAS：1112994-35-0