JNJ-17156516 is a potent, and selective cholecystokinin 1 receptor antagonist. JNJ-17156516 expressed high-affinity at the cloned human (pK(I) = 7.96 +/- 0.11), rat (pK(I) = 8.02 +/- 0.11), and canine (pK(I) = 7.98 +/- 0.04) CCK1 receptors, and it was also highly selective for the CCK1 receptor compared with the CCK2 receptor across the same species ( approximately 160-, approximately 230-, and approximately 75-fold, respectively). References: Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester. Acta Crystallogr C. 2009 Apr;65(Pt 4):o163-6. doi: 10.1107/S010827010900941X. Epub 2009 Mar 21. PubMed PMID: 19346614; PubMed Central PMCID: PMC2724994.

纯度：≥98%

CAS：649551-06-4