JNJ-10258859 is a potent, and selective phosphodiesterase type 5 inhibitor. JNJ-10258859 inhibits phosphodiesterase type 5 with a K(i) of 0.23 nM and displayed excellent selectivity versus phosphodiesterase types 1-4 (>/=22,000 fold compared to phosphodiesterase type 5). JNJ-10258859 could be a useful treatment for erectile dysfunction. References: Qiu Y, Bhattacharjee S, Kraft P, John TM, Craig E, Haynes-Johnson D, Guan J, Jiang W, Macielag M, Sui Z, Clancy J, Lundeen S. Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859. Eur J Pharmacol. 2003 Jul 4;472(1-2):73-80. PubMed PMID: 12860475.

纯度：≥98%

CAS：374927-03-4