JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50 = 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity. In vivo experiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38. References: Hamilton JY, Sarlah D, Carreira EM. Iridium-catalyzed enantioselective allyl-alkene coupling. J Am Chem Soc. 2014 Feb 26;136(8):3006-9. doi: 10.1021/ja412962w. Epub 2014 Feb 12. PubMed PMID: 24521052.

纯度：≥98%

CAS：1146594-87-7