重组信号调节蛋白α

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重组信号调节蛋白α

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

产品名称

重组信号调节蛋白α(SIRPa)
Recombinant Sirpa

产品介绍

基因名：

Sirpa

产品别名：

AI835480； Bit； CD172a； Idd13.2； P84； Ptpns1； SHP-1； SHPS-1； SIRP； Sirpa； signal-regulatory protein alpha； signal-regulatory protein alpha； tyrosine-protein phosphatase non-receptor type substrate 1； CD172 antigen-like family member A； SHP substrate 1； brain Ig-like molecule with tyrosine-based activation motifs； brain immunological-like with tyrosine-based motifs； inhibitory receptor SHPS-1； mSIRP-alpha1； myD-1 antigen； protein tyrosine phosphatase, non-receptor type substrate 1； signal-regulatory protein alpha-1； sirp-alpha-1；信号调节蛋白α；信号调节蛋白α(SIRPa)；

背景信息：

Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。