基因名：
Fkbp8
产品别名：
38kDa； FKBP-38； FKBP-8； FKBPR38； Fkbp38； mFKBP38； Fkbp8； FK506 binding protein 8； FK506 binding protein 8； peptidyl-prolyl cis-trans isomerase FKBP8； 38 kDa FK506-binding protein； 38 kDa FKBP； FK506-binding protein 38； PPIase FKBP8； rotamase； FK506结合蛋白38； FK506结合蛋白8(FKBP8)； 肽基脯氨酸异构酶酶FKBP8；
背景信息：
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.
Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A. Interacts with ZFYVE27; may negatively regulate ZFYVE27 phosphorylation.
Tissue specificity: Widely expressed. Highest levels seen in the brain.
标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
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