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重组胞苷尿苷鸟苷结合蛋白1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

产品名称
Recombinant CELF1
Recombinant CUGBP Elav-like family member 1 protein
产品介绍
基因名:

CELF1


产品别名:

BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; NAB50; NAPOR; hNab50; CELF1; CUGBP Elav-like family member 1; CUGBP Elav-like family member 1; CUGBP Elav-like family member 1; 50 kDa nuclear polyadenylated RNA-binding protein; CUG RNA-binding protein; CUG triplet repeat RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; EDEN-BP homolog; RNA-binding protein BRUNOL-2; bruno-like 2; bruno-like protein 2; deadenylation factor CUG-BP; embryo deadenylation element binding protein; embryo deadenylation element-binding protein homolog; nuclear polyadenylated RNA-binding protein, 50-kD; 胞苷尿苷鸟苷结合蛋白1;


背景信息:
Myotonic dystrophy (DM) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3’-untranslated region of the myotonin protein kinase gene (DMPK). CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA. In normal cells, CUG-BP1 up-regulates the p21 protein during differentiation by inducing the translation of p21 via binding to a GC-rich sequence located within the 5’ region of p21 mRNA. In DM cells, failure to accumulate CUG-BP1 leads to a reduction of p21 and alterations in other proteins responsible for cell cycle withdrawl.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。