基因名：
SMAD3
产品别名：
HSPC193； HsT17436； JV15-2； LDS1C； LDS3； MADH3； hMAD-3； hSMAD3； mad3； SMAD3； SMAD family member 3； SMAD family member 3； mothers against decapentaplegic homolog 3； MAD homolog 3； MAD, mothers against decapentaplegic homolog 3； SMA- and MAD-related protein 3； SMAD, mothers against DPP homolog 3； mad homolog JV15-2； mad protein homolog； mothers against DPP homolog 3； Smad同源物3(SMAD3)； 磷酸化细胞信号转导分子SMAD3； 细胞信号转导分子SMAD3；
背景信息：
Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD3 binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. It also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. SMAD3 has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive.
标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
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