SCH-442416 is a selective adenosine A2A receptor antagonist. SCH-442416 binds to human and rat A2A receptors with high affinity (Kis are 0.048 and 0.5 nM respectively). It exhibits > 23000-fold selectivity for hA2A over hA1 in vitro with minimal affinity for hA2B and hA3 receptors (IC50 > 10 μM). References: Kang X, Yu J, Wei Y, Zhao P. The effect of A 2A receptor antagonist (SCH 442416) on the mRNA expression of Kir 2.1 and Kir 4.1 channels in rat retinal Müller cells under hypoxic conditions in vitro. Adv Clin Exp Med. 2013 Nov-Dec;22(6):825-9. PubMed PMID: 24431311.

纯度：≥98%

CAS：316173-57-6