Description: KN-93 is a potent, cell-permeable, reversible and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.37 μM, and with no remarkable inhibitory effects on APK, PKC, MLCK or Ca2+-PDE activities. KN-93 suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer. KN-93 ameliorates levodopa-induced dyskinesia in a rat model of Parkinson's disease. KN-93 protects rat cerebral cortical neurons from N-methyl-D-aspartic acid-induced injury.

References: Biochem Biophys Res Commun. 1991 Dec 31;181(3):968-75; Neuropsychiatr Dis Treat. 2013;9:1213-20.

Related CAS #: 1188890-41-6 (phosphate) 1956426-56-4(HCI) 139298-40-1 (free base).

纯度：≥98%